This article was originally published on 27.1.2016 and has now been updated with new information.
Teva api utilizes exceptional fermentation production capabilities, technologies, processes and R&D services to meet the highest industry standards.
We operate state-of-the-art, high-capacity fermentation plants with total fermenter capacity of nearly 2000 m3. Operated by skilled and experienced professionals, these fully-automated production plants implement complex fermentations, including highly-controlled fed batch and bioconversion processes even in 100 m3 bioreactors, and the subsequent recovery processes.
Beside the traditional fermentation operations, the most complex upstream and downstream processes can be handled by our equipment and experts.
Our proven fermentation production capabilities cover a broad range of technologies and classical fermentation products from antibiotics, statins, antifungal compounds and immunosuppressants to enzymes and high-potent compounds.
Selected fermentation APIs include Deferoxamine Mesylate, Lovastatin, Mupirocin, Pravastatin Sodium, Tobramycin, Tacrolimus monohydrate, and Simvastatin. We also have fermentation intermediaries of semisynthetic products like Deferoxamine Mesylate, Lovastatin, Mupirocin, Pravastatin Sodium, Tobramycin, Tacrolimus monohydrate and Simvastatin.
Teva api provides industry-leading R&D services throughout the product lifecycle. Our R&D expertise includes strain and technology development processes designed to continuously improve process productivity and product quality for both new compounds and existing products.
We have a high-level experience in strain improvement, upstream and downstream process improvement and process scale up from laboratory to pilot and further to production scale.
Strain improvement activities incorporate both modern molecular/genetic and classical methods that deliver the most robust and productive strains for commercial scale. Organism types vary from bacteria and filamentous fungi to recombinant enzyme production hosts.
We have extensive experience developing classical and modern biotechnological, enzymatic and whole-cell bioconversion processes involving multidisciplinary teams of molecular biologists, microbiologists, bioengineers, enzyme and process chemists.
Fermentation over the years
The Teva api Debrecen site has more than half a century of experience in the development, scale up and production of classical fermentation products. Over the years, the Teva api fermentation team has led multiple process scale up and technology transfer projects that have strengthened our competencies in related areas such as QA and regulatory compliance.
Our R&D and production experts cooparate closely to ensure our processes operate at peak efficiency and at the highest quality all the time.
By fully utilizing our deep expertise of the fermentation production process – from cellular pathways to engineering practices – we are able to handle even your very specific and complex needs.