About the API
Simvastatin belongs to the class of lipid-lowering compounds known as ‘statins’. Generally, statins work by reducing the level of low-density lipoprotein (LDL) cholesterol in the blood by inhibiting the liver enzyme responsible for its production.
High blood cholesterol levels are associated with cardiovascular diseases such as dyslipidemia (abnormal blood lipid level) and atherosclerosis (narrowing of the artery walls by accumulation of fatty deposits, or ‘plaques’). Accordingly, statins are mainly indicated for the prevention and treatment of such diseases.
Simvastatin is typically prescribed as an adjunct to a cholesterol-reduced diet.
After patent expiry in 2006, simvastatin has become available in several generic formulations.
Simvastatin’a synthetic derivative of a fermentation product of Aspergillus terreus’is presently manufactured by large-scale fermentation, a well-established industrial method using microorganisms to convert raw materials to valuable commercial product through chemical transformations. Through careful strain selection and continuous strain improvement, the process has been streamlined for maximum productivity and yield.