General Information
Pemetrexed is a drug that belongs to a class of molecules termed folate antimetabolites and is used in the treatment of aggressive and late stage cancers. Pemetrexed inhibits three enzymes involved in the folate pathway: thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).
About the API
Systematic name
(2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid
Trade name(s)
Alimta
Technology
High Potent
Molecular Formula
C20H21N5O6
Molecular Weight
427.41 g/mol
Physical properties
White to off-white solid
Therapeutic category
Oncology
Available formulations
Injectables
Regulations
EU DMF
Japan DMF
Korea DMF
Other
US DMF
EU DMF
Japan DMF
Korea DMF
Other
US DMF