Ivosidenib API

CAS 1448347-49-6

General Information

Ivosidenib, sold under the brand name Tibsovo, is used in adults whose cancer is newly diagnosed and who are either 75 years and older or cannot be treated with other anticancer drugs. Ivosidenib blocks the protein made by the mutated IDH1 gene. Blocking this protein may help keep cancer cells from growing. Ivosidenib is a type of enzyme inhibitor and a type of targeted therapy for patients diagnosed with Glioma, Acute Myeloid Leukemia (AML), Cholangiocarcinoma, and Chondrosarcoma.

About the API

Systematic name (2S)-N-[(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
Trade name(s) Tibsovo
Technology Synthetic
Molecular Formula C28H22ClF3N6O3
Molecular Weight 582.97 g/mol
Therapeutic category Oncology
Available formulations Oral Solid