Nomegestrol Acetate

CAS 58652-20-3

About the API

Systematic name [(8S,9S,10R,13S,14S,17R)-17-acetyl-6,13-dimethyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate
Trade name(s) Lutenyl, Nogest; Zoely/ Naemis (with Estradiol)
Molecular Formula C23H30O4
Molecular Weight 370.48 g/mol
Physical properties White to off-white non-hygroscopic crystalline powder
Therapeutic category Endocrinology & metabolism
Available formulations Oral Solid
Regulations CEP Flag CEP EU DMF Flag EU DMF

General Information

Nomegestrol acetate belongs to a class of steroid hormones called progestins, which are synthetic analogues of the naturally-occurring hormone progesterone. It is an oral contraceptive that can be used alone or in combination with estradiol. Nomegestrol acetate is characterized by high selectivity, binding to and activating the progesterone receptor to inhibit ovulation.

Nomegestrol acetate, abbreviated as NOMAC, was first introduced in the mid-1980s and is used in the treatment of gynecological disorders, in hormone replacement therapy (HRT) for menopausal symptoms, and in hormonal contraceptives