Linaclotide

CAS 851199-60-5

About the API

Therapeutic category Gastroenterology
Available formulations Oral Solid
Regulations US DMF Flag US DMF

Mechanism of action

Linaclotide is structurally related to human guanylin and uroguanylin and functions as a guanylate cyclase-C  agonist.

Both linaclotide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium. Activation of GC-C results in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate.