General Information
Abrocitinib API is a small-molecule inhibitor of Janus kinase 1 (JAK1). Janus kinases are intracellular enzymes that play a crucial role in transduction pathways responsible for regulating hematopoiesis and immune cell function. The Janus kinase (JAK) – signal transducer and activator of transcription (STAT) signaling pathway holds a central position in the pathogenesis of numerous autoimmune and inflammatory diseases. In its finished dose it is indicated for the treatment of moderate-to-severe atopic dermatitis.
About the API
Systematic name
N-((1s,3s)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl) propane-1 Sulfonamide
Trade name(s)
Cibinqo
Technology
Synthetic
Molecular Formula
C14H21N5O2S
Molecular Weight
323.42 g/mol
Physical properties
White to pale-yellow powder
Therapeutic category
Dermatology