Venlafaxine HCl

CAS 99300-78-4

About the API

Systematic name (RS)-1-[2-dimethylamino-1-(4-methoxyphenyl)-ethyl]cyclohexanol
Trade name(s) Effexor, Efexor
Technology Synthetic Organic Chemistry
Molecular Formula C17H28ClNO2
Molecular Weight 277.4018 g/mol
Physical properties white/off-white crystalline solid
Therapeutic category Neurology-Psychiatry
Available formulations Oral Solid Oral Solid Long-Acting
Regulations CEP Flag CEP EU DMF Flag EU DMF Other Flag Other US DMF Flag US DMF

General Information

Venlafaxine hcl First introduced in 1993, venlafaxine was the sixth most widely used antidepressant in the US in 2007 (17.1 million, based on the amount of retail prescriptions).

The drug is indicated for the treatment of major depressive/bipolar mood disorders, and is an effective treatment for those diagnosed with anxiety disorders (general, social anxiety, panic disorder).

Venlafaxine is both structurally and pharmacologically unique to other antidepressants on the market for treatment of generalized anxiety disorders. It is often effective for depressive disorders where traditional SSRIs have no effect.


First disclosed in 1986 (Biochem. Pharmacol. 35(24): 4493; U.S. Pat. No. 4,609,758), generic formulations of venlafaxine have been available on the market since 2006.

Presently, venlafaxine hydrochloride is manufactured through efficient large-scale synthetic organic chemistry methods starting from simple, commercially available (petrochemical) precursors.