Sugammadex Sodium

CAS 0343306-71-8

About the API

Systematic name 6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-cyclodextrin sodium salt(1
Molecular Formula C72H104Na8O48S8
Molecular Weight 2178.01 g/mol
Physical properties Clear
Therapeutic category Muscle relaxant
Available formulations Injectables
Regulations Brazil DMF Flag Brazil DMF EU DMF Flag EU DMF US DMF Flag US DMF

General Information

Sugammadex Sodium belongs to a class of drugs called selective relaxant binding agents (SRBAs), used to cancel the effects of neuromuscular blocking agents (NMBAs). NMBAs are used during surgery and other medical procedures for anesthetic purposes (specifically, to provide skeletal muscle relaxation).  Sugammadex is used to reverse the effects of the NMBAs rocuronium and vecuronium bromide in adults. In the EU, it is also approved for use in children from age 2 to reverse the effects of rocuronium.

Administered as an intravenous infusion, sugammadex can provide rapid reversal when needed, and can be used to reverse both shallow and profound neuromuscular block. In addition, it obviates the need for co-administration with antimuscarinic agents since it does not inhibit the enzyme acetylcholinesterase.