Quetiapine Fumarate

CAS 111974-72-2

About the API

Systematic name 2-{2-[4-(Dibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy}ethanol (2E)-2-butenedioate (2
Trade name(s) Seroquel
Technology Synthetic Organic Chemistry
Molecular Formula (C21H25N3O2S)2?C4H4O4
Molecular Weight 499.579 g/mol (883.11 g/mol as fumarate salt)
Physical properties white to off-white crystalline solid
Therapeutic category Neurology-Psychiatry
Available formulations Oral Solid Oral Solid Long-Acting
Regulations CEP Flag CEP EU DMF Flag EU DMF Other Flag Other US DMF Flag US DMF

General Information

Quetiapine is a psychotropic medication belonging the benzisoxazole chemical class. Quetiapine fumarate (also known as Seroquel) is a formulation in which the active pharmaceutical ingredient is provided as the fumarate salt.

 

The medication is indicated for the treatment of schizophrenia as well as for treatment of manic episodes linked to bipolar I disorder. Off-label uses include treatment for: Alzheimer’s, anxiety, attention deficit hyperactivity disorder, dementia, and mood disorder, among other conditions.

 

The drug was originally disclosed in 1989 (U.S Pat. No. 4,879,288). Since its patent expiration (March 2012), quetiapine has become available in several generic formulations.

 

Presently, quetiapine is manufactured through efficient large-scale synthetic organic chemistry methods starting from simple, commercially available (petrochemical) precursors.