About the API
Quetiapine is a psychotropic medication belonging the benzisoxazole chemical class. Quetiapine fumarate (also known as Seroquel) is a formulation in which the active pharmaceutical ingredient is provided as the fumarate salt.
The medication is indicated for the treatment of schizophrenia as well as for treatment of manic episodes linked to bipolar I disorder. Off-label uses include treatment for: Alzheimer’s, anxiety, attention deficit hyperactivity disorder, dementia, and mood disorder, among other conditions.
The drug was originally disclosed in 1989 (U.S Pat. No. 4,879,288). Since its patent expiration (March 2012), quetiapine has become available in several generic formulations.
Presently, quetiapine is manufactured through efficient large-scale synthetic organic chemistry methods starting from simple, commercially available (petrochemical) precursors.