About the API
Nitrofurantoin is an oral antibiotic with a particularly low rate of bacterial resistance, used for urinary tract infections caused by susceptible strains of Escherichia coli or Staphylococcus saprophyticus. It is widely used as a short-term treatment for acute urinary tract infections, or as long-term treatment for the prevention (prophylaxis) of recurrent infections in people prone to them.
Nitrofurantoin is produced in macrocrystalline form or as a monohydrate powder. Some medicinal products contain both forms, allowing for a dual mode of drug release. Macrocrystalline nitrofurantoin has slower dissolution and absorption rates than does nitrofurantoin monohydrate. Nitrofurantoin monohydrate, upon exposure to gastric and intestinal fluids, forms a gel matrix that releases nitrofurantoin over time.