General Information
Memantine Hydrochloride is the hydrochloride salt of memantine, a low-affinity, voltage-dependent, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Memantine binds to and inhibits cation channels of glutamanergic NMDA receptors located in the central nervous system (CNS), preventing the prolonged influx of calcium ions and the associated neuronal excitotoxicity, and thereby potentially enhancing cognitive function. Memantine is also a 5-hydroxytryptamine type 3 (5HT3) receptor and nicotinic receptor antagonist.
About the API
Technology
Synthetic
Therapeutic category
Neurology-Psychiatry
Available formulations
Oral Liquid
Oral Solid
Oral Solid Long-Acting
Regulations
CADIFA
Canada DMF
EU DMF
US DMF
CADIFA
Canada DMF
EU DMF
US DMF