Irbesartan, structurally defined as a nonpeptide tetrazole derivative, is an angiotensin receptor blocker (ARB) used primarily for the treatment of hypertension. Irbesartan can be used alone, but is often prescribed with other medications, e.g. hydrochlorothiazide (marketed as Avalide) to treat hypertension.
Irbesartan may also slow the advancement of diabetic nephropathy, a disease of the blood vessels within the kidneys; for this reason, the drug is also used to treat kidney disorders in patients having both type-II diabetes and hypertension.
The U.S. FDA has recently approved (April 2012) the first generic versions of irbesartan (brand name Avapro). Presently, irbesartan is manufactured through an efficient large-scale multi-step synthetic organic process starting from simple, commercially available (petrochemical) precursors.