CAS 138402-11-6

General Information

Irbesartan, structurally defined as a nonpeptide tetrazole derivative, is an angiotensin receptor blocker (ARB) used primarily for the treatment of hypertension. Irbesartan can be used alone, but is often prescribed with other medications, e.g. hydrochlorothiazide (marketed as Avalide) to treat hypertension.


Irbesartan may also slow the advancement of diabetic nephropathy, a disease of the blood vessels within the kidneys; for this reason, the drug is also used to treat kidney disorders in patients having both type-II diabetes and hypertension.


The U.S. FDA has recently approved (April 2012) the first generic versions of irbesartan (brand name Avapro). Presently, irbesartan is manufactured through an efficient large-scale multi-step synthetic organic process starting from simple, commercially available (petrochemical) precursors.

About the API

Systematic name 2-Butyl-3-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one
Technology Synthetic
Molecular Formula C25H28N6O
Molecular Weight 428.529 g/mol
Physical properties white to off-white crystalline solid
Therapeutic category Cardiovascular
Available formulations Oral Solid
Regulations Canada DMF Flag Canada DMF CEP Flag CEP EU DMF Flag EU DMF Korea DMF Flag Korea DMF US DMF Flag US DMF