General Information
Ciclosporine is an immunosuppressant isolated from the fungus Tolypocladium inflatum. It is prescribed to prevent rejection of newly transplanted organs and tissues. Specifically, ciclosporin is a calcineurin inhibitor that targets the activity of T-cells, a type of white blood cell involved in fighting foreign substances the body is exposed to. It is also used in the treatment of rheumatoid arthritis when methotraxate treatment alone is not effective, Crohn’s disease, and other autoimmune disorders.
About the API
Systematic name
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,3 1-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
Trade name(s)
Gengraf, Neoral, Sandimmune
Technology
Fermentation
Molecular Formula
C62H111N11O12
Molecular Weight
1202.61 g/mol
Physical properties
white to off-white crystalline powder
Therapeutic category
Immunology
Available formulations
Injectables
Opthalmic
Oral Liquid
Oral Solid
Regulations
Canada DMF
CEP
EU DMF
Japan DMF
Korea DMF
Other
US DMF
Canada DMF
CEP
EU DMF
Japan DMF
Korea DMF
Other
US DMF