CAS 59865-13-3

General Information

Ciclosporine is an immunosuppressant isolated from the fungus Tolypocladium inflatum. It is prescribed to prevent rejection of newly transplanted organs and tissues. Specifically, ciclosporin is a calcineurin inhibitor that targets the activity of T-cells, a type of white blood cell involved in fighting foreign substances the body is exposed to. It is also used in the treatment of rheumatoid arthritis when methotraxate treatment alone is not effective, Crohn’s disease, and other autoimmune disorders.

About the API

Systematic name (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,3 1-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
Trade name(s) Gengraf, Neoral, Sandimmune
Technology Fermentation
Molecular Formula C62H111N11O12
Molecular Weight 1202.61 g/mol
Physical properties white to off-white crystalline powder
Therapeutic category Immunology
Available formulations Injectables Opthalmic Oral Liquid Oral Solid
Regulations Canada DMF Flag Canada DMF CEP Flag CEP EU DMF Flag EU DMF Japan DMF Flag Japan DMF Korea DMF Flag Korea DMF Other Flag Other US DMF Flag US DMF