General Information
Bempedoic Acid API is a novel small molecule inhibitor of triphosphate-citrate lyase (ACL). It is indicated as an adjunctive therapy, along with diet and statin treatment, for adults with refractory hypercholesterolemia. By blocking cholesterol synthesis in the liver, Bacid effectively reduces LDL-C levels, mitigating the risk of atherosclerotic plaques and cardiovascular events. It was approved for use by the FDA in 2020, along with a combination product Bempedoic Acid and Ezetimibe.
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Manufacture
About the API
Systematic name
8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic Acid
Trade name(s)
Nexletol
Technology
Synthetic
Molecular Formula
C19H36O5
Molecular Weight
344.5 g/mol
Physical properties
White to off-white solid
Therapeutic category
Endocrinology
Available formulations
Oral Solid