Baricitinib

CAS 1187594-09-7

About the API

Systematic name 2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile
Technology Synthetic Organic Chemistry
Molecular Formula C16H17N7O2S
Molecular Weight 371.4 g/mol
Therapeutic category Rheumatology
Available formulations Oral Solid

General Information

Baricitinib is an orally bioavailable inhibitor of Janus kinases 1 and 2 (JAK1/2), with potential anti-inflammatory, immunomodulating and antineoplastic activities. Baricitinib is indicated for treating adults with moderate to severe rheumatoid arthritis who have not responded well enough to or could not tolerate at least one tumor necrosis factor antagonist.

Upon administration, baricitinib binds to JAK1/2, which inhibits JAK1/2 activation and leads to the inhibition of the JAK-signal transducers and activators of transcription (STAT) signaling pathway. This decreases the production of inflammatory cytokines and may prevent an inflammatory response. In addition, baricitinib may induce apoptosis and reduce proliferation of JAK1/2-expressing tumor cells. JAK kinases are intracellular enzymes involved in cytokine signaling, inflammation, immune function and hematopoiesis; they are also upregulated and/or mutated in various tumor cell types.