General Information
Baricitinib is an orally bioavailable inhibitor of Janus kinases 1 and 2 (JAK1/2), with potential anti-inflammatory, immunomodulating and antineoplastic activities. Baricitinib is indicated for treating adults with moderate to severe rheumatoid arthritis who have not responded well enough to or could not tolerate at least one tumor necrosis factor antagonist.
About the API
Systematic name
2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile
Technology
Synthetic
Molecular Formula
C16H17N7O2S
Molecular Weight
371.4 g/mol
Therapeutic category
Rheumatology
Available formulations
Oral Solid