Acyclovir

CAS 59277-89-3

About the API

Systematic name 2-amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one
Trade name(s) Zovirax
Technology Synthetic Organic Chemistry
Molecular Formula C8H11N5O3
Molecular Weight 225.20 g/mol
Physical properties White crystalline powder
Therapeutic category Dermatology
Available formulations Opthalmic Oral Liquid Oral Solid Topical / Dermatological
Regulations Brazil DMF Flag Brazil DMF Canada DMF Flag Canada DMF CEP Flag CEP US DMF Flag US DMF

General Information

Acyclovir is a purine nucleoside analogue and belongs to a class of molecules termed antivirals. It is used for the treatment of viral infections caused by herpes simplex virus (including cold sores and genital herpes), herpes zoster (shingles), varicella zoster (chicken pox).

Acyclovir is prescribed for genital herpes to both reduce pain and the number of sores in initial cases, as well as, decrease the incidence and severity of recurrent outbreaks.

When used to treat shingles, this drug has the ability to reduce pain, shorten healing time, limit transmission to uninfected individuals, and reduce the formation of new sores. In patients with chicken pox, it can shorten healing time, restrict the number of sores produced, and reduce fever if administered within 24 hours of onset. Acyclovir is administered in both topical ointment and intravenous forms depending on the type of viral infection.

Acyclovir became FDA approved for the treatment of herpes simplex virus infections under the trade name Zovirax in 1982.

It is currently manufactured through large-scale synthetic organic chemistry methods starting from simple, commercially available precursors.